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Manuel Gonzalez-Guerrero

Posted by | February 28, 2021


Manuel Gonzalez-Guerrero

Job Title:

Group Leader


Phone Number:

+34 913364558


Google Scholar Profile


My career has been focused on transition metal (iron, copper, zinc, molybdenum,…) transport. I obtained my PhD at Universidad de Granada-CSIC in 2005 working on mechanisms of metal tolerance in arbuscular mycorrhizal fungi. I did three postdocs: metal imaging in arbuscular mycorrhizal fungi (2006), structure-function of metal transporting P-type ATPases (2006-2009), and, as a Marie Curie fellow, biochemistry of Arabidopsis iron transporter IRT1 (2010). On 2011, I joined Centro de Biotecnología y Genómica de Plantas (UPM-INIA) as a Ramón y Cajal Fellow, in a tenure-like position. After obtaining a ERC Starting Grant in 2014, I was tenured and became a Group Leader. My group is interested in studying how plant-associated microorganisms affect and are affected by transition metal homeostasis in the host plant. Using as a model Medicago truncatula, we have been able to determine the pathway that metals primarily use to reach the nodule and identified the transporters responsible for iron, zinc, and molybdate uptake by rhizobia-infected nodule cells.

Research Areas:

  • Nitrogen fixation
  • Plant metal nutrition
  • Transition metal homeostasis

Current N-related Projects:


Castro-Rodríguez R, Abreu I, Reguera M, Novoa-Aponte L, Mijovilovich A, Escudero V, Jiménez-Pastor FJ, Abadía J, Wen J, Mysore KS, Álvarez-Fernández A, Küpper H, Imperial J, González-Guerrero M (2020). Medicago truncatula Yellow Stripe1-Like3 gene is involved in vascular delivery of transition metals to root nodules. J. Exp. Bot. 71: 7257-7269.

Escudero V, Abreu I, Tejada-Jiménez M, Rosa-Núñez E, Quintana J, Prieto RI, Larue C, Wen J, Villanova J, Mysore KS, Argüello JM, Castillo-Michel H, Imperial J, González-Guerrero M (2020). Medicago truncatula Ferroportin2 mediates iron import into nodule symbiosomes. New Phytol. 228:194-209

Escudero V, Abreu I, del Sastre E, Tejada-Jiménez M, Larue C, Novoa-Aponte L, Castillo-González J, Wen J, Mysore KS, Abadía J, Argüello JM, Castillo-Michel H, Álvarez-Fernández A, Imperial J, González-Guerrero M (2020). Nicotianamine synthase2 is required for symbiotic nitrogen fixation in Medicago truncatula nodules. Front. Plant Sci. 10:1780.

Gil-Díez P, Tejada-Jiménez M, León-Mediavilla J, Wen J, Mysore KS, Imperial J, González-Guerrero M (2019). MtMOT1.2 is responsable for molybdate supply to Medicago truncatula nodules. Plant Cell Environ. 42: 310-320.

León-Mediavilla J, Senovilla M, Montiel J, Gil-Díez P, Saez A, Kryvoruchko IS, Reguera M, Udvardi MK, Imperial J, González-Guerrero M (2018) MtMTP2-facilitated zinc transport into intracelular compartments is essential for nodule development in Medicago truncatulaFront. Plant Sci. 9: 990.

Senovilla M, Castro-Rodríguez R, Abreu I, Escudero V, Kryvoruchko I, Udvardi MK, Imperial J, González-Guerrero M (2018). Medicago truncatula copper transporter1 (MtCOPT1) delivers copper for symbiotic nitrogen fixation. New Phytol. 218: 696-709.

Tejada-Jiménez M, Gil-Diez P, León Mediavilla J, Wen J, Mysore KS, Imperial J, González- Guerrero M (2017) Medicago truncatula Molybdate Transporter type1 (MOT1.3) is a plasma membrane molybdenum transporter required for nitrogenase activity in root nodules under molybdenum deficiency. New Phytol., 216, 1223-1235.

Abreu I, Saez A, Castro-Rodríguez R, Escudero V, Rodríguez-Haas B, Senovilla M, Larue C, Grolimund D, Tejada-Jiménez M, Imperial J, González-Guerrero M (2017) Medicago truncatula Zinc-Iron Permease6 provides zinc to rhizobia-infected nodule cells. Plant Cell Environ., 40, 2706-2719.

González-Guerrero M, Escudero V, Saez A, Tejada-Jiménez M (2016) Transition metal transport in plants and associated endosymbionts. Arbuscular mycorrhizal fungi and rhizobia. Front. Plant Sci., 7, 1088.

Tejada-Jiménez M, Castro-Rodríguez R, Kryvoruchko M, Lucas MM, Udvardi M, Imperial J, González-Guerrero M (2015). Medicago truncatula Natural Resistance Associated Macrophage Protein1 is required for iron uptake by rhizobia-infected nodule cells. Plant Physiol. 168:258-272.

González-Guerrero M, Matthiadis A, Saez A, Long TA (2014). Fixating in metals: New insights into the role of metals in nodulation and symbiotic nitrogen fixation. Front. Plant Sci. 5: 45..

Benito B, González-Guerrero M (2014). Unravelling potassium nutrition in ectomycorrhizal associations. New Phytol. 201:707-709.

Zielazinski EL, González-Guerrero M, Subramanian P, Stemmler TL, Argüello JM, Rosenzweig AC (2013). Sinorhizobium meliloti Nia is a P(1B-5)-ATPase expressed in the nodule during plant symbosis and is involved in Ni and Fe transport. Metallomics 5:1614-1623.

Rodríguez-Haas B, Finney L, Vogt S, González-Melendi P, Imperial J. González-Guerrero M (2013). Iron distribution through the developmental stages of Medicago truncatula nodules. Metallomics 5:1247-1253.